Selected structures determined by our group

Several assembly structures of efflux pumps

“Recent paradigm shift in the assembly of bacterial tripartite efflux pumps and the type 1 secretion system”, Review article
Journal of Microbiology (2019)

Overall structure of HlyD.

“Crystal Structure of a Soluble Fragment of the Membrane Fusion Protein HlyD in a Type 1 Secretion System of Gram-Negative Bacteria”
Structure (2016)

Cryo-EM MAP fitted with a pseudoatomic model of the complex.

“Pseudoatomic Structure of the Tripartite Multidrug Efflux Pump AcrAB-TolC Reveals the Intermeshing Cogwheel-like interaction between AcrA and TolC”
Structure (2016)

 TEM images and a docked model of the AcrAB-TolC efflux pump.

“Structure of the Tripartite Multidrug Efflux Pump AcrAB-TolC Suggests an Alternative Assembly Mode”
Mol. Cells. (2015)

TEM images and a docked model of the AcrBA fusion protein as well as the TolC α-hairpin tip-containing MacA protein.

“Structure of the Tripartite Multidrug Efflux Pump AcrAB-TolC Suggests an Alternative Assembly Mode”
Mol. Cells. (2015)

structural models of A. actinomycetemcomitans MacA-OprMα hybrid dimer.

“Assembly and Channel Opening of Outer Membrane Protein in Tripartite Drug Efflux Pumps of Gram-negative Bacteria”
J. Biol. Chem. (2012)

Crystal structure of MacA, the hexameric assembly of MFP.

“Crystal structure of the Periplasmic Component of a Tripartite Macrolide-Specific Efflux Pump”
Mol. Biol. (2009)